EFFECT OF BILE STONE ULTRASTRUCTURE AND MINERAL COMPOSITION ON DEVELOPMENT OF OXIDATIVE STRESS IN GALLSTONE DISEASE
Kolmakova Tatyana Sergeevna - Doctor of Biology, Associate Professor, Head of the Department of Medical Biology and Genetics, Rostov State Medical University, Russian Federation, Russia, 344022, Rostov-on-Don, Nakhichevansky lane, 29, 8(863)201-44-05, tat_kolmakova@mail.ru
Yalovega Galina Eduardovna - Doctor of Physical and Mathematical Sciences, Associate Professor, Head of the Department of Physics of Nanosystems and Spectroscopy, Southern Federal University , Russia, 344090, Rostov-on-Don, str. Zorge, 5, yalovega@sfedu.ru
Oksenyuk Oksana Stanislavna - Candidate of Medical Sciences, Head of the Central Research Laboratory, Rostov State Medical University, Russia, 344022, Rostov-on-Don, Nakhichevansky lane , 29, oksenuk_o@bk.ru
Brzhezinskaya Maria - Doctor of Physical and Mathematical Sciences (Dr. habil.), Helmholtz-Zentrum Berlin f?r Materialien und Energie GmbH, Str. Albert-Einstein, 15, 12489 Berlin, Germany, maria.brzhezinskaya@helmholtz-berlin.de
Smirnova Olga Borisovna - Candidate of Biological Sciences, Associate Professor, , Senior Researcher, Central Research Laboratory, Rostov State Medical University, Russia, 344022, Rostov-on-Don, Nakhichevansky lane, 29, zolochevskaj51@mail.ru
Belikova Elena Aleksandrovna - Candidate of Biological Sciences, Associate Professor of the Department of Medical Biology and Genetics, Rostov State Medical University, Russia, 344022, Rostov-on-Don, Nakhichevansky lane , 29, belikova8@mail.ru
Aslanov Albert Mikhailovich - Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases, Rostov State Medical University, Russian Federation, 344022, Rostov-on-Don, Nakhichevansky lane , 29, aslanov.a@bk.ru
The article provides research data on the possible connection of the chemical composition and ultrastructure of different types of gallstones and oxidative stress in the pathogenesis of cholelithiasis (GI). Gallstones of all types have been found to have a maximum accumulation of metals in the peripheral layer. Ca, Fe, Zn, Cu were found in all samples. A decrease in antioxidant protection in the blood of patients with acute and chronic forms of cholelithiasis has been established. The authors believe that there is a pathogenetic link between a decrease in the activity of metalloprotein enzymes of antioxidant protection, the accumulation of metals in the gallstones and the formation of inflammation in the gallbladder.
Key words: mineral composition of gallstones, chemical elements, ultrastructure, cholelithiasis, stages of gallstones formation, oxidative stress, antioxidant system. stages of gallstones formation.
