INFLUENCE OF THE NELUMBO NUCIFERA EXTRACTS ON THE PHYSIOLOGICAL PARAMETERS OF THE FEMALE RATS LIVER AGAINST THE BACKGROUND OF EXPOSURE TO CARBON TETRACHLORIDE
Kondratenko Elena Igorevna - doctor of biological sciences, professor, dean of the Faculty of biology, Astrakhan State University, 414000, Astrakhan, Shaumyan, sq. 1, condr70@mail.ru
Lomteva Natalya Arkadyevna - Doctor of Biological Sciences, Associate Professor,, Acting Head of the Department of Physiology, Morphology, Genetics and Biomedicine, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, pl. Shaumyan, 1, physiology-agu@mail.ru
Abdelkhamid Khassan Mustafa Salakhheldin - assistant professor, Zagazig University, 44519 Ismailia - El-Zakazik Rd, Shaibet an Nakareyah, Zagazig 2, Ash Sharqia Governorate, Egypt,
The aim of this work was to study the effect of the extract of the nelumbo nucifera fruit-pods on the physiological parameters of the female rats liver induced by carbon tetrachloride damage. In the work, the morphofunctional parameters of the liver of rats were studied under the influence of carbon tetrachloride with the introduction of an nelumbo nucifera extract. In animals, the activity of alkaline phosphatase (AP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin in blood serum was evaluated. It was established that the studied nelumbo nucifera extract at doses of 50 and 100 mg/kg of body weight significantly reduces the level of ALT, AST, total bilirubin in the blood serum in comparison with similar indicators in animals with CCl4-induced liver damage, returning the indicators to the initial values of the control groups, while exhibiting a protective effect. The hepatoprotective effect of the nelumbo nucifera studied extract manifests itself through the restoration of the main biochemical parameters and the improvement of the morphological and functional characteristics of the liver parenchyma. The effectiveness of the fruit-boxes nelumbo nucifera extract is comparable to the well-known hepatoprotective drug - silymarin.
Key words: morphophysiological parameters of the live, nelumbo nucifera extracts, hepatoprotective properties, CCl4-induced liver damage
