BEHAVIORAL REACTIONS AND FREE RADICAL HOMEOSTASIS IN HYPERTHYROIDISM AND HYPOTHYROIDISM

Pohmelnova Mariya S.  -  Student, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, marusya-pohmelnova@mail.ru

Viktorova Alina F.  -  Student, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, alinenok556@mail.ru

Kuleshova Olga N.  -  Ph. D. (Biology), Senior Researcher, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, pozdniakova_olga@list.ru

We studied behavioral reactions and dynamics of free radical homeostasis of male white rats in Hyper-and hypofunctions of the thyroid gland. High doses of L-thyroxine and Mercazolil were used in a short time. Exposure to both substances suppressed locomotor and research activity, animals with experimentally induced hyperthyroidism showed a decrease in erythrocyte peroxide hemolysis and an increase in total antioxidant activity, and animals with hypothyroidism were characterized by an increase in erythrocyte peroxide hemolysis and a sharp decrease in total antioxidant activity.

Key words: hyperthyroidism, hypothyroidism, animal behavior, males, free radical homeostasis, Mercazolil, L-thyroxin, thyroid hormones, thyroid gland