EFFECTS OF A-TOCOPHEROL ACETATE ON THE BEHAVIOR OF PRENATALLY STRESSED IMMATURE RATS

Kuleshova Olga N.  -  Ph. D. (Biology), Senior Researcher, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, pozdniakova_olga@list.ru

Teply David Lvovich  -  Doctor of Biological Sciences, Professor, Professor of the Department of Fundamental Biology, Astrakhan State University named by V.N. Tatischev, Russia, 414056, Astrakhan, Shaumyan sq., 1,

Adverse effects during intrauterine development increase the level of anxiety and become risk factors for depression. Alpha-tocopherol acetate has antioxidant and antiapoptotic efficacy and may have a preventive effect. The Suok test model was chosen to study the behavior of immature (20 days) albino rats of both sexes. Prenatal ?-tocopherol (from days 2 to 19 of prenatal development, 1 mg/100 g body weight) returned a number of stress-modified (immobilization in plastic cases for 3 hours from days 16 to 19 of prenatal ontogenesis) behavioral parameters to the control values: the number of short grooming acts and the level of sensorimotor disintegration regardless of sex, stops in females and the time spent in the light part of the test in males. In males, the number of border crossings and horizontal activity in the light part of the test increased, but the autonomic stress index and the duration of stops increased. Thus, a-TF is a promising drug for further study to protect the central nervous system of the fetus, exposed to the negative effects of stress during the period of active development, regardless of gender.

Key words: prenatal stress, immobilization, rats, immature, females, males, behavior, Suok test.