NONINVASIVE STIMULATION OF LYMPHATIC CLEANSING OF BRAIN TISSUES FROM BLOOD AND TOXINS IN RODENTS WITH GLIOMA

Sarantseva Elena Ivanovna  -  candidate of biological sciences, Associate Professor, Department of Human and Animal Physiology, Saratov National Research State University named after N.G. Chernyshevsky, Russin Federation, 410012, Saratov, st. Astrakhanskaya, 83, sophora@mail.ru

Iskra Tatyana Dmitrievna  -  candidate of biological sciences, Associate Professor, Department of Human and Animal Physiology, Saratov National Research State University named after N.G. Chernyshevsky, Russian Federation, 410012, Saratov, st. Astrakhanskaya, 83, tata-isk@yandex.ru

Navolokin Nikita Aleksandrovich  -  Candidate of Medical Sciences, Senior Researcher at the Smart Sleep Lab, Saratov State Medical University named by V. I. Razumovsky, Russia, 410012, Saratov, Bolshaya Kazachya st., 112,

The study of brain cleansing mechanisms is one of the priority research objectives in the field of the diagnostics and therapy of neurological diseases and pathophysiological conditions. Photostimulation, or phototherapy, is the most promising therapeutic method due to its ability to modulate cellular and molecular processes, which allows to restore the functions of the central nervous system. Priority in scientific research is given to the detailed study of the effect of photobiomodulation on the processes of brain cleansing and to developing new therapeutic approaches for treating brain pathologies. These studies were focused on developing a non-invasive technology for suppressing glioma growth in mice using photodynamic therapy with a wavelength of 1270 nm. Studies were conducted to study the role of the lymphatic system of the brain in cleansing its tissues from erythrocytes and hemosiderin. The studies have shown that the lymphatic system of the brain performs the function of cleansing its tissues from blood after a hemorrhage. Transcranial photodynamic exposure had a stimulating effect on the removal of hemosiderin from brain tissue and the rate of lymph flow. The results obtained are progressive and pioneering and have no analogues in the world.

Key words: photobiomodulation, brain diseases, lymphatic cleansing, hemosiderin, glioma, confocal visualization