SPECTROPHOTOMETRIC STUDY OF THE PROCESSES OF COMPLEX FORMATION OF NICOTINIC ACID WITH TITANIUM (IV) IN THE PRESENCE OF ORTHOAMINOPHENOL IN CONNECTION WITH THE INFLUENCE OF THE DRUG ON THE PROCESSES OF VITAL ACTIVITY AND HUMAN HEALTH AND CONTROL OF ITS CONSUMPTION

Klementyeva Alexandra Vladimirovna  -  Candidate of Chemical Sciences, Associate Professor , Associate Professor of the Department of Fundamental and Applied Chemistry, Federal State Budgetary Educational Institution of Higher Education "Astrakhan State University named by V.N. Tatishchev", Russia, 414056, Astrakhan, st. Tatishcheva, 20a, klementeva98@gmail.com

The research presents a technique for spectrophotometric determination of the effect of the medicinal preparation nicotinic acid as a stabilizer on the processes of titanium (IV) complexation with the organic reagent ortho-aminophenol. Based on the results of the studies, conclusions were made on the conditions of formation of new complex compounds, mechanisms of complexation processes and stability of the obtained compounds, and assumptions were made on the mechanism of the observed color reactions and the structure of the resulting coordination units. The technique uses a spectrophotometric method of analysis based on color reactions of formation of complex compounds of d-elements with organic reagents. The following reagents were used to obtain color reactions of complexation: a solution of TiCl4 salt; an organic reagent ortho-aminophenol and the medicinal preparation nicotinic acid. The studied system (Ti(IV) – ortho-aminophenol – nicotinic acid) can be proposed for quantitative determination of nicotinic acid in medicinal preparations for the purpose of identification and quality control, since overdose or non-compliance with quality (counterfeit) have facts of manifestation of its negative influence on the quality of human life or threat to public health. Niacin deficiency can cause pellagra, mainly in countries with a high level of food security; at the same time, pellagra causes photosensitivity, rash, mucositis, gastrointestinal dysfunction and neuropsychiatric dysfunctions.

Key words: B vitamins, identification and quality control, complexometry, medicinal product, organic reagent, metabolite, human quality of life, stability of the complex